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KMID : 1134820170460091045
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Journal of the Korean Society of Food Science and Nutrition
2017 Volume.46 No. 9 p.1045 ~ p.1052
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Genotoxicity Studies on Corn Silk Extract Containing High Maysin
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Ha Ae-Wha
Kang Hyeon-Jung
Kim Sun-Lim
Kim Myung-Hwan
Kim Woo-Kyung
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Abstract
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In this study, a battery of genetic-toxicity studies on corn silk extract with high maysin content were performed according to internationally accepted protocols. In a mutation test using Salmonella Typhimurium TA1535, TA1537, TA98, and TA100, the number of mutant colonies did not significantly increase up to a maximum concentration of 5,000 μg/plate in the presence or absence of the S9 metabolic activation system. In the chromosome aberration test using Chinese hamster lung fibroblasts, negative results were observed in the concentration up to 1,250 μg/mL of corn silk extract. In the micronucleus test using ICR mice, incidence of polymorphonuclear erythrocytes with a maximum concentration of 2,000 mg/kg corn silk extract did not show any significant difference compared to the negative control group. Based on these results, the test substance, con silk extract, did not influence genotoxicity.
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KEYWORD
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corn silk, genotoxicity, reverse mutation, micronucleus test, chromosome aberration
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